I have been using DIM Skin Mix and the Pre + Probiotic Vitamin Supplement together for a month and have now signed up for the autoship of these two because my skin has been doing so well. I'm 37 and started getting "under the skin" pimples around my chin and jaw area. They weren't white heads and I'm assuming they were due to changes in my hormones. I could tell a difference within a week of using these two supplements. I'm not sure if I could do one without the other... I may try that at a later date, but since they're working with keeping my skin clear, I'm not going to change anything up for a while. Highly recommend these over buying more products to put on externally.